coronavirus

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Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the common cold (which is also caused by other viruses, predominantly rhinoviruses), while more lethal varieties can cause SARS, MERS, and COVID-19. In cows and pigs they cause diarrhea, while in mice they cause hepatitis and encephalomyelitis.

Coronaviruses constitute the subfamily Orthocoronavirinae, in the family Coronaviridae, order Nidovirales, and realm Riboviria. They are enveloped viruses with a positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry. The genome size of coronaviruses ranges from approximately 26 to 32 kilobases, one of the largest among RNA viruses. They have characteristic club-shaped spikes that project from their surface, which in electron micrographs create an image reminiscent of the solar corona, from which their name derives.

The name "coronavirus" is derived from Latin corona, meaning "crown" or "wreath", itself a borrowing from Greek κορώνη korṓnē, "garland, wreath". The name was coined by June Almeida and David Tyrrell who first observed and studied human coronaviruses. The word was first used in print in 1968 by an informal group of virologists in the journal Nature to designate the new family of viruses. The name refers to the characteristic appearance of virions (the infective form of the virus) by electron microscopy, which have a fringe of large, bulbous surface projections creating an image reminiscent of the solar corona or halo. This morphology is created by the viral spike peplomers, which are proteins on the surface of the virus.

The scientific name Coronavirus was accepted as a genus name by the International Committee for the Nomenclature of Viruses (later renamed International Committee on Taxonomy of Viruses) in 1971. As the number of new species increased, the genus was split into four genera, namely Alphacoronavirus, Betacoronavirus, Deltacoronavirus, and Gammacoronavirus in 2009. The common name coronavirus is used to refer to any member of the subfamily Orthocoronavirinae. As of 2020, 45 species are officially recognised.

The earliest reports of a coronavirus infection in animals occurred in the late 1920s, when an acute respiratory infection of domesticated chickens emerged in North America. Arthur Schalk and M.C. Hawn in 1931 made the first detailed report which described a new respiratory infection of chickens in North Dakota. The infection of new-born chicks was characterized by gasping and listlessness with high mortality rates of 40–90%. Leland David Bushnell and Carl Alfred Brandly isolated the virus that caused the infection in 1933. The virus was then known as infectious bronchitis virus (IBV). Charles D. Hudson and Fred Robert Beaudette cultivated the virus for the first time in 1937. The specimen came to be known as the Beaudette strain. In the late 1940s, two more animal coronaviruses, JHM that causes brain disease (murine encephalitis) and mouse hepatitis virus (MHV) that causes hepatitis in mice were discovered. It was not realized at the time that these three different viruses were related.

Human coronaviruses were discovered in the 1960s using two different methods in the United Kingdom and the United States. E.C. Kendall, Malcolm Bynoe, and David Tyrrell working at the Common Cold Unit of the British Medical Research Council collected a unique common cold virus designated B814 in 1961. The virus could not be cultivated using standard techniques which had successfully cultivated rhinoviruses, adenoviruses and other known common cold viruses. In 1965, Tyrrell and Bynoe successfully cultivated the novel virus by serially passing it through organ culture of human embryonic trachea. The new cultivating method was introduced to the lab by Bertil Hoorn. The isolated virus when intranasally inoculated into volunteers caused a cold and was inactivated by ether which indicated it had a lipid envelope. Dorothy Hamre and John Procknow at the University of Chicago isolated a novel cold from medical students in 1962. They isolated and grew the virus in kidney tissue culture, designating it 229E. The novel virus caused a cold in volunteers and, like B814, was inactivated by ether.

Scottish virologist June Almeida at St. Thomas Hospital in London, collaborating with Tyrrell, compared the structures of IBV, B814 and 229E in 1967. Using electron microscopy the three viruses were shown to be morphologically related by their general shape and distinctive club-like spikes. A research group at the National Institute of Health the same year was able to isolate another member of this new group of viruses using organ culture and named one of the samples OC43 (OC for organ culture). Like B814, 229E, and IBV, the novel cold virus OC43 had distinctive club-like spikes when observed with the electron microscope.

The IBV-like novel cold viruses were soon shown to be also morphologically related to the mouse hepatitis virus. This new group of viruses were named coronaviruses after their distinctive morphological appearance. Human coronavirus 229E and human coronavirus OC43 continued to be studied in subsequent decades. The coronavirus strain B814 was lost. It is not known which present human coronavirus it was. Other human coronaviruses have since been identified, including SARS-CoV in 2003, HCoV NL63 in 2003, HCoV HKU1 in 2004, MERS-CoV in 2013, and SARS-CoV-2 in 2019. There have also been a large number of animal coronaviruses identified since the 1960s.

Coronaviruses are large, roughly spherical particles with unique surface projections. Their size is highly variable with average diameters of 80 to 120 nm. Extreme sizes are known from 50 to 200 nm in diameter. The total molecular mass is on average 40,000 kDa. They are enclosed in an envelope embedded with a number of protein molecules. The lipid bilayer envelope, membrane proteins, and nucleocapsid protect the virus when it is outside the host cell.

The viral envelope is made up of a lipid bilayer in which the membrane (M), envelope (E) and spike (S) structural proteins are anchored. The molar ratio of E:S:M in the lipid bilayer is approximately 1:20:300. The E and M protein are the structural proteins that combined with the lipid bilayer to shape the viral envelope and maintain its size. S proteins are needed for interaction with the host cells. But human coronavirus NL63 is peculiar in that its M protein has the binding site for the host cell, and not its S protein. The diameter of the envelope is 85 nm. The envelope of the virus in electron micrographs appears as a distinct pair of electron-dense shells (shells that are relatively opaque to the electron beam used to scan the virus particle).

The M protein is the main structural protein of the envelope that provides the overall shape and is a type III membrane protein. It consists of 218 to 263 amino acid residues and forms a layer 7.8 nm thick. It has three domains, a short N-terminal ectodomain, a triple-spanning transmembrane domain, and a C-terminal endodomain. The C-terminal domain forms a matrix-like lattice that adds to the extra-thickness of the envelope. Different species can have either N- or O-linked glycans in their protein amino-terminal domain. The M protein is crucial during the assembly, budding, envelope formation, and pathogenesis stages of the virus lifecycle.

The E proteins are minor structural proteins and highly variable in different species. There are only about 20 copies of the E protein molecule in a coronavirus particle. They are 8.4 to 12 kDa in size and are composed of 76 to 109 amino acids. They are integral proteins (i.e. embedded in the lipid layer) and have two domains namely a transmembrane domain and an extramembrane C-terminal domain. They are almost fully α-helical, with a single α-helical transmembrane domain, and form pentameric (five-molecular) ion channels in the lipid bilayer. They are responsible for virion assembly, intracellular trafficking and morphogenesis (budding).

The spikes are the most distinguishing feature of coronaviruses and are responsible for the corona- or halo-like surface. On average a coronavirus particle has 74 surface spikes. Each spike is about 20 nm long and is composed of a trimer of the S protein. The S protein is in turn composed of an S1 and S2 subunit. The homotrimeric S protein is a class I fusion protein which mediates the receptor binding and membrane fusion between the virus and host cell. The S1 subunit forms the head of the spike and has the receptor-binding domain (RBD). The S2 subunit forms the stem which anchors the spike in the viral envelope and on protease activation enables fusion. The two subunits remain noncovalently linked as they are exposed on the viral surface until they attach to the host cell membrane. In a functionally active state, three S1 are attached to two S2 subunits. The subunit complex is split into individual subunits when the virus binds and fuses with the host cell under the action of proteases such as cathepsin family and transmembrane protease serine 2 (TMPRSS2) of the host cell.

S1 proteins are the most critical components in terms of infection. They are also the most variable components as they are responsible for host cell specificity. They possess two major domains named N-terminal domain (S1-NTD) and C-terminal domain (S1-CTD), both of which serve as the receptor-binding domains. The NTDs recognize and bind sugars on the surface of the host cell. An exception is the MHV NTD that binds to a protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). S1-CTDs are responsible for recognizing different protein receptors such as angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), and dipeptidyl peptidase 4 (DPP4).

A subset of coronaviruses (specifically the members of betacoronavirus subgroup A) also has a shorter spike-like surface protein called hemagglutinin esterase (HE). The HE proteins occur as homodimers composed of about 400 amino acid residues and are 40 to 50 kDa in size. They appear as tiny surface projections of 5 to 7 nm long embedded in between the spikes. They help in the attachment to and detachment from the host cell.

Inside the envelope, there is the nucleocapsid, which is formed from multiple copies of the nucleocapsid (N) protein, which are bound to the positive-sense single-stranded RNA genome in a continuous beads-on-a-string type conformation. N protein is a phosphoprotein of 43 to 50 kDa in size, and is divided into three conserved domains. The majority of the protein is made up of domains 1 and 2, which are typically rich in arginines and lysines. Domain 3 has a short carboxy terminal end and has a net negative charge due to excess of acidic over basic amino acid residues.

Coronaviruses contain a positive-sense, single-stranded RNA genome. The genome size for coronaviruses ranges from 26.4 to 31.7 kilobases. The genome size is one of the largest among RNA viruses. The genome has a 5′ methylated cap and a 3′ polyadenylated tail.

The genome organization for a coronavirus is 5′-leader-UTR-replicase (ORF1ab)-spike (S)-envelope (E)-membrane (M)-nucleocapsid (N)-3′UTR-poly (A) tail. The open reading frames 1a and 1b, which occupy the first two-thirds of the genome, encode the replicase polyprotein (pp1ab). The replicase polyprotein self cleaves to form 16 nonstructural proteins (nsp1–nsp16).

The later reading frames encode the four major structural proteins: spike, envelope, membrane, and nucleocapsid. Interspersed between these reading frames are the reading frames for the accessory proteins. The number of accessory proteins and their function is unique depending on the specific coronavirus.

Infection begins when the viral spike protein attaches to its complementary host cell receptor. After attachment, a protease of the host cell cleaves and activates the receptor-attached spike protein. Depending on the host cell protease available, cleavage and activation allows the virus to enter the host cell by endocytosis or direct fusion of the viral envelope with the host membrane.

On entry into the host cell, the virus particle is uncoated, and its genome enters the cell cytoplasm. The coronavirus RNA genome has a 5′ methylated cap and a 3′ polyadenylated tail, which allows it to act like a messenger RNA and be directly translated by the host cell's ribosomes. The host ribosomes translate the initial overlapping open reading frames ORF1a and ORF1b of the virus genome into two large overlapping polyproteins, pp1a and pp1ab.

The larger polyprotein pp1ab is a result of a -1 ribosomal frameshift caused by a slippery sequence (UUUAAAC) and a downstream RNA pseudoknot at the end of open reading frame ORF1a. The ribosomal frameshift allows for the continuous translation of ORF1a followed by ORF1b.

The polyproteins have their own proteases, PLpro (nsp3) and 3CLpro (nsp5), which cleave the polyproteins at different specific sites. The cleavage of polyprotein pp1ab yields 16 nonstructural proteins (nsp1 to nsp16). Product proteins include various replication proteins such as RNA-dependent RNA polymerase (nsp12), RNA helicase (nsp13), and exoribonuclease (nsp14).

A number of the nonstructural proteins coalesce to form a multi-protein replicase-transcriptase complex. The main replicase-transcriptase protein is the RNA-dependent RNA polymerase (RdRp). It is directly involved in the replication and transcription of RNA from an RNA strand. The other nonstructural proteins in the complex assist in the replication and transcription process. The exoribonuclease nonstructural protein, for instance, provides extra fidelity to replication by providing a proofreading function which the RNA-dependent RNA polymerase lacks.

Replication – One of the main functions of the complex is to replicate the viral genome. RdRp directly mediates the synthesis of negative-sense genomic RNA from the positive-sense genomic RNA. This is followed by the replication of positive-sense genomic RNA from the negative-sense genomic RNA.

Transcription – The other important function of the complex is to transcribe the viral genome. RdRp directly mediates the synthesis of negative-sense subgenomic RNA molecules from the positive-sense genomic RNA. This process is followed by the transcription of these negative-sense subgenomic RNA molecules to their corresponding positive-sense mRNAs. The subgenomic mRNAs form a "nested set" which have a common 5'-head and partially duplicate 3'-end.

Recombination – The replicase-transcriptase complex is also capable of genetic recombination when at least two viral genomes are present in the same infected cell. RNA recombination appears to be a major driving force in determining genetic variability within a coronavirus species, the capability of a coronavirus species to jump from one host to another and, infrequently, in determining the emergence of novel coronaviruses. The exact mechanism of recombination in coronaviruses is unclear, but likely involves template switching during genome replication.

The replicated positive-sense genomic RNA becomes the genome of the progeny viruses. The mRNAs are gene transcripts of the last third of the virus genome after the initial overlapping reading frame. These mRNAs are translated by the host's ribosomes into the structural proteins and many accessory proteins. RNA translation occurs inside the endoplasmic reticulum. The viral structural proteins S, E, and M move along the secretory pathway into the Golgi intermediate compartment. There, the M proteins direct most protein-protein interactions required for the assembly of viruses following its binding to the nucleocapsid. Progeny viruses are then released from the host cell by exocytosis through secretory vesicles. Once released the viruses can infect other host cells.

Infected carriers are able to shed viruses into the environment. The interaction of the coronavirus spike protein with its complementary cell receptor is central in determining the tissue tropism, infectivity, and species range of the released virus. Coronaviruses mainly target epithelial cells. They are transmitted from one host to another host, depending on the coronavirus species, by either an aerosol, fomite, or fecal-oral route.

Human coronaviruses infect the epithelial cells of the respiratory tract, while animal coronaviruses generally infect the epithelial cells of the digestive tract. SARS coronavirus, for example, infects the human epithelial cells of the lungs via an aerosol route by binding to the angiotensin-converting enzyme 2 (ACE2) receptor. Transmissible gastroenteritis coronavirus (TGEV) infects the pig epithelial cells of the digestive tract via a fecal-oral route by binding to the alanine aminopeptidase (APN) receptor.

Coronaviruses form the subfamily Orthocoronavirinae, which is one of two sub-families in the family Coronaviridae, order Nidovirales, and realm Riboviria. They are divided into the four genera: Alphacoronavirus, Betacoronavirus, Gammacoronavirus and Deltacoronavirus. Alphacoronaviruses and betacoronaviruses infect mammals, while gammacoronaviruses and deltacoronaviruses primarily infect birds.

The most recent common ancestor (MRCA) of all coronaviruses is estimated to have existed as recently as 8000 BCE, although some models place the common ancestor as far back as 55 million years or more, implying long term coevolution with bat and avian species. The most recent common ancestor of the alphacoronavirus line has been placed at about 2400 BCE, of the betacoronavirus line at 3300 BCE, of the gammacoronavirus line at 2800 BCE, and the deltacoronavirus line at about 3000 BCE. Bats and birds, as warm-blooded flying vertebrates, are an ideal natural reservoir for the coronavirus gene pool (with bats the reservoir for alphacoronaviruses and betacoronavirus – and birds the reservoir for gammacoronaviruses and deltacoronaviruses). The large number and global range of bat and avian species that host viruses have enabled extensive evolution and dissemination of coronaviruses.

Many human coronaviruses have their origin in bats. The human coronavirus NL63 shared a common ancestor with a bat coronavirus (ARCoV.2) between 1190 and 1449 CE. The human coronavirus 229E shared a common ancestor with a bat coronavirus (GhanaGrp1 Bt CoV) between 1686 and 1800 CE. More recently, alpaca coronavirus and human coronavirus 229E diverged sometime before 1960. MERS-CoV emerged in humans from bats through the intermediate host of camels. MERS-CoV, although related to several bat coronavirus species, appears to have diverged from these several centuries ago. The most closely related bat coronavirus and SARS-CoV diverged in 1986. The ancestors of SARS-CoV first infected leaf-nose bats of the genus Hipposideridae; subsequently, they spread to horseshoe bats in the species Rhinolophidae, then to Asian palm civets, and finally to humans.

Unlike other betacoronaviruses, bovine coronavirus of the species Betacoronavirus 1 and subgenus Embecovirus is thought to have originated in rodents and not in bats. In the 1790s, equine coronavirus diverged from the bovine coronavirus after a cross-species jump. Later in the 1890s, human coronavirus OC43 diverged from bovine coronavirus after another cross-species spillover event. It is speculated that the flu pandemic of 1890 may have been caused by this spillover event, and not by the influenza virus, because of the related timing, neurological symptoms, and unknown causative agent of the pandemic. Besides causing respiratory infections, human coronavirus OC43 is also suspected of playing a role in neurological diseases. In the 1950s, the human coronavirus OC43 began to diverge into its present genotypes. Phylogentically, mouse hepatitis virus (Murine coronavirus), which infects the mouse's liver and central nervous system, is related to human coronavirus OC43 and bovine coronavirus. Human coronavirus HKU1, like the aforementioned viruses, also has its origins in rodents.

Coronaviruses vary significantly in risk factor. Some can kill more than 30% of those infected, such as MERS-CoV, and some are relatively harmless, such as the common cold. Coronaviruses can cause colds with major symptoms, such as fever, and a sore throat from swollen adenoids. Coronaviruses can cause pneumonia (either direct viral pneumonia or secondary bacterial pneumonia) and bronchitis (either direct viral bronchitis or secondary bacterial bronchitis). The human coronavirus discovered in 2003, SARS-CoV, which causes severe acute respiratory syndrome (SARS), has a unique pathogenesis because it causes both upper and lower respiratory tract infections.

Six species of human coronaviruses are known, with one species subdivided into two different strains, making seven strains of human coronaviruses altogether.

Four human coronaviruses produce symptoms that are generally mild, even though it is contended they might have been more aggressive in the past:

Three human coronaviruses produce potentially severe symptoms:

These cause the diseases commonly called SARS, MERS, and COVID-19 respectively.

Although the common cold is usually caused by rhinoviruses, in about 15% of cases the cause is a coronavirus. The human coronaviruses HCoV-OC43, HCoV-HKU1, HCoV-229E, and HCoV-NL63 continually circulate in the human population in adults and children worldwide and produce the generally mild symptoms of the common cold. The four mild coronaviruses have a seasonal incidence occurring in the winter months in temperate climates. There is no preponderance in any season in tropical climates.

In 2003, following the outbreak of severe acute respiratory syndrome (SARS) which had begun the prior year in Asia, and secondary cases elsewhere in the world, the World Health Organization (WHO) issued a press release stating that a novel coronavirus identified by several laboratories was the causative agent for SARS. The virus was officially named the SARS coronavirus (SARS-CoV). More than 8,000 people from 29 different countries and territories were infected, and at least 774 died.

In September 2012, a new type of coronavirus was identified, initially called Novel Coronavirus 2012, and now officially named Middle East respiratory syndrome coronavirus (MERS-CoV). The World Health Organization issued a global alert soon after. The WHO update on 28 September 2012 said the virus did not seem to pass easily from person to person. However, on 12 May 2013, a case of human-to-human transmission in France was confirmed by the French Ministry of Social Affairs and Health. In addition, cases of human-to-human transmission were reported by the Ministry of Health in Tunisia. Two confirmed cases involved people who seemed to have caught the disease from their late father, who became ill after a visit to Qatar and Saudi Arabia. Despite this, it appears the virus had trouble spreading from human to human, as most individuals who are infected do not transmit the virus. By 30 October 2013, there were 124 cases and 52 deaths in Saudi Arabia.

After the Dutch Erasmus Medical Centre sequenced the virus, the virus was given a new name, Human Coronavirus—Erasmus Medical Centre (HCoV-EMC). The final name for the virus is Middle East respiratory syndrome coronavirus (MERS-CoV). The only U.S. cases (both survived) were recorded in May 2014.

In May 2015, an outbreak of MERS-CoV occurred in the Republic of Korea, when a man who had traveled to the Middle East, visited four hospitals in the Seoul area to treat his illness. This caused one of the largest outbreaks of MERS-CoV outside the Middle East. As of December 2019, 2,468 cases of MERS-CoV infection had been confirmed by laboratory tests, 851 of which were fatal, a mortality rate of approximately 34.5%.

In December 2019, a pneumonia outbreak was reported in Wuhan, China. On 31 December 2019, the outbreak was traced to a novel strain of coronavirus, which was given the interim name 2019-nCoV by the World Health Organization (WHO), later renamed SARS-CoV-2 by the International Committee on Taxonomy of Viruses.

As of 20 May 2021, there have been at least 3,417,961 confirmed deaths and more than 164,913,259 confirmed cases in the COVID-19 pandemic. The Wuhan strain has been identified as a new strain of Betacoronavirus from group 2B with approximately 70% genetic similarity to the SARS-CoV. The virus has a 96% similarity to a bat coronavirus, so it is widely suspected to originate from bats as well.

Coronaviruses have been recognized as causing pathological conditions in veterinary medicine since the 1930s. They infect a range of animals including swine, cattle, horses, camels, cats, dogs, rodents, birds and bats. The majority of animal related coronaviruses infect the intestinal tract and are transmitted by a fecal-oral route. Significant research efforts have been focused on elucidating the viral pathogenesis of these animal coronaviruses, especially by virologists interested in veterinary and zoonotic diseases.

Coronaviruses infect domesticated birds. Infectious bronchitis virus (IBV), a type of coronavirus, causes avian infectious bronchitis. The virus is of concern to the poultry industry because of the high mortality from infection, its rapid spread, and its effect on production. The virus affects both meat production and egg production and causes substantial economic loss. In chickens, infectious bronchitis virus targets not only the respiratory tract but also the urogenital tract. The virus can spread to different organs throughout the chicken. The virus is transmitted by aerosol and food contaminated by feces. Different vaccines against IBV exist and have helped to limit the spread of the virus and its variants. Infectious bronchitis virus is one of a number of strains of the species Avian coronavirus. Another strain of avian coronavirus is turkey coronavirus (TCV) which causes enteritis in turkeys.

Coronaviruses also affect other branches of animal husbandry such as pig farming and the cattle raising. Swine acute diarrhea syndrome coronavirus (SADS-CoV), which is related to bat coronavirus HKU2, causes diarrhea in pigs. Porcine epidemic diarrhea virus (PEDV) is a coronavirus that has recently emerged and similarly causes diarrhea in pigs. Transmissible gastroenteritis virus (TGEV), which is a member of the species Alphacoronavirus 1, is another coronavirus that causes diarrhea in young pigs. In the cattle industry bovine coronavirus (BCV), which is a member of the species Betacoronavirus 1 and related to HCoV-OC43, is responsible for severe profuse enteritis in young calves.

Coronaviruses infect domestic pets such as cats, dogs, and ferrets. There are two forms of feline coronavirus which are both members of the species Alphacoronavirus 1. Feline enteric coronavirus is a pathogen of minor clinical significance, but spontaneous mutation of this virus can result in feline infectious peritonitis (FIP), a disease with high mortality. There are two different coronaviruses that infect dogs. Canine coronavirus (CCoV), which is a member of the species Alphacoronavirus 1, causes mild gastrointestinal disease. Canine respiratory coronavirus (CRCoV), which is a member of the species Betacoronavirus 1 and related to HCoV-OC43, cause respiratory disease. Similarly, there are two types of coronavirus that infect ferrets. Ferret enteric coronavirus causes a gastrointestinal syndrome known as epizootic catarrhal enteritis (ECE), and a more lethal systemic version of the virus (like FIP in cats) known as ferret systemic coronavirus (FSC).

Coronaviruses infect laboratory animals. Mouse hepatitis virus (MHV), which is a member of the species Murine coronavirus, causes an epidemic murine illness with high mortality, especially among colonies of laboratory mice. Prior to the discovery of SARS-CoV, MHV was the best-studied coronavirus both in vivo and in vitro as well as at the molecular level. Some strains of MHV cause a progressive demyelinating encephalitis in mice which has been used as a murine model for multiple sclerosis. Sialodacryoadenitis virus (SDAV), which is a strain of the species Murine coronavirus, is highly infectious coronavirus of laboratory rats, which can be transmitted between individuals by direct contact and indirectly by aerosol. Rabbit enteric coronavirus causes acute gastrointestinal disease and diarrhea in young European rabbits. Mortality rates are high.

A number of vaccines using different methods have been developed against human coronavirus SARS-CoV-2. Antiviral targets against human coronaviruses have also been identified such as viral proteases, polymerases, and entry proteins. Drugs are in development which target these proteins and the different steps of viral replication.

Vaccines are available for animal coronaviruses IBV, TGEV, and Canine CoV, although their effectiveness is limited. In the case of outbreaks of highly contagious animal coronaviruses, such as PEDV, measures such as destruction of entire herds of pigs may be used to prevent transmission to other herds.

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RT @MehralseineZahl: Wir erinnern an Kimberlys Mum, die das beste Essen kochen und die besten Geschichten erzählen konnte. #mehralsnurein…
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RT @Adade_EConsult: 🖥️ Jornadas virtuales: Las emociones y el Covid-19 en la Seguridad y Salud en el Trabajo 📅 8 y 9 de febrero + INFO: h…
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Captain Sir Tom Moore dies aged 100 after contracting coronavirus and pneumonia
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Captain Sir Tom Moore, who raised almost £33m for the UK’s NHS, has died with coronavirus
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"None of us were able to predict" coronavirus would mutate or variants would emerge - Dido Harding, head of the Nat…
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Kristi Noem bragging about her state's handling of the coronavirus pandemic is slightly better than the captain of…
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RT @Suntimes: Illinois public health officials Wednesday announced another record for COVID-19 doses administered in a day, as residents sw…
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RT @LePoint: Didier Raoult publiera, jeudi 11 février, un livre de près de 500 pages compilant ses analyses et autres interventions relati…
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RT @CNN: A CDC ensemble forecast now projects there will be 496,000 to 534,000 coronavirus deaths in the US by February 27. At least 446,9…
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RT @NoticiasCaracol: #LoÚltimo | Minsalud confirma 11.025 nuevos contagios con coronavirus y 301 fallecidos en el país. En total, hay 2.125…
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Coronavirus is in the air — there’s too much focus on surfaces
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RT @Cleavon_MD: ⚠️dead at 33 Israel Tolentino Jr., firefighter from Passaic, New Jersey died from #COVID. "This virus has left us with a v…
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RT @CHVNoticias: Colegio Médico respalda la seguridad y eficiencia de la vacuna CoronaVac de Sinovac
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Sağlık çalışmalarımız coronavirus nedeni ile olmelwri durumunda ŞEHİT sayılmalı. Allah şehidimize rahmet eylesin .
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#Coronavirus De las 1.952.744 personas que tuvieron el virus, ya son 1.745.208 los recuperados y 158.997 los que aú…
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RT @CarlosM66066760: El SUP pide que las bajas por coronavirus de la Policía cuenten como enfermedad profesional ví…
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RT @PiePony1: All prosecutions under new Coronavirus Act unlawful, review finds
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RT @Mippcivzla: 📌 𝙄𝙣𝙛𝙤́𝙧𝙢𝙖𝙩𝙚 🧬 Reduce el riesgo de infección del Coronavirus (Covid-19) con las siguientes medidas al ir en un vehículo…
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RT @reuterspictures: Health workers sped along the Amazon to start vaccinating riverside communities, bringing hope to a region hard hit by…
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Here's a look at Cobb County and state coronavirus numbers reported Wednesday, and how they compare to the day befo…
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Yahoo: “Dr. Anthony Fauci is warning America to “just lay low" rather than gathering for Super Bowl parties on Sund…
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RT @ShamsCharania: Zero NBA players tested positive for coronavirus out of 482 tested since Jan. 27, sources tell @TheAthletic @Stadium.
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RT @NESnmahp: Please share & follow @healthlitplace #HealthLiteracy #Coronavirus #COVID19
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1) ESTRATEGIA COVID-CERO En Taiwan acaba de morir la novena persona por coronavirus. Sí, has leído bien: en un año…
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🗣️ ¡𝐓𝐎𝐌𝐀 𝐏𝐑𝐄𝐂𝐀𝐔𝐂𝐈𝐎́𝐍 ! ✍️🇻🇪 Ya que el Coronavirus se puede transmitir fácilmente de persona a persona, es necesar…
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If you think we can’t afford COVID relief, here’s your reminder that America’s billionaires could pay for every cen…
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Looks like the company got a coronavirus boost anyway...
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RT @KatyJayne101: Dido Harding who was paid £12bn of public money to head up Test and Trace could not predict that coronavirus would mutate…
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RT @sapna: this is so pure 💛
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RT @Mippcivzla: 🗣️¡𝐓𝐎𝐌𝐀 𝐏𝐑𝐄𝐂𝐀𝐔𝐂𝐈𝐎́𝐍!✍️🇻🇪 Ya que el Coronavirus se puede transmitir fácilmente de persona a persona, es necesario adoptar m…
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RT @betebonilha: Que notícia maravilhosa que chegou de Cuba, eles vão oferecer vacina contra o coronavírus para turistas que visitarem a il…
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RT @LivUni: Don’t forget we have a great range of free activities and resources for those of you home schooling or staying at home. From c…
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RT @rafa_cavada: Este articulo dice otra cosa
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The disease Coronavirus has ruined lives. Integrity — and independence — concern me deeply. “How much do you va…
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RT @thejimjams: Andrew Cuomo Announces Indoor Dining Can Resume Despite Coronavirus Being Worse Than When He Banned It
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RT @Mippcivzla: 🗣️¡𝐄𝐒 𝐂𝐎𝐍𝐓𝐈𝐆𝐎! ✍️🇻🇪 Evitar la propagación de las enfermedades respiratorias agudas es evitar la entrada del Coronavirus. Se…
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RT @Cooperativa: #CooperativaEnCasa Alcalde Jadue después que Contraloría le exigiera informar sobre adquisición y uso del fármaco Avifavir…
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RT @France24_en: A 🇩🇪 German military plane carrying over 20 medical workers, together with ventilators and hospital beds touched down in #…
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RT @bellezatuyera: ✍️🇻🇪 Ya que el Coronavirus se puede transmitir fácilmente de persona a persona, es necesario adoptar medidas higiénicas…
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RT @Medicilio: El #coronavirus ha invisibilizado muchas patologías como el #cancer que siguen existiendo y no admiten el retraso que están…
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Tarrant County surpasses 2,300 COVID deaths with 15 on Thursday including woman in 30s
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RT @AP: Wisconsin’s Republican-controlled Legislature repealed Democratic Gov. Tony Evers’ mask mandate, brushing aside warnings from healt…
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RT @danieljadue: Hoy 155 fallecidos por Coronavirus y algunos pretenden que nos quedemos de brazos cruzados. Toda alternativa para esta pan…
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RT @eluniversocom: Reino Unido se une a laboratorio alemán para crear vacunas más efectivas contra las variantes del coronavirus ►
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RT @VicGovDH: Yesterday there were 0 new cases reported. 23,227 test results were received - thank you for getting tested. #EveryTestHelps…
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Evening Summary > Germany Nord Stream 2 We're Having That > Coronavirus Man Found Alive 20 Days After His Funeral >…
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As of Friday, there were 775,622 confirmed cases of COVID-19 and 13,948 coronavirus-related deaths in Arizona.
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🇺🇸 O presidente Joe Biden e a vice-presidente Kamala Harris se encontraram hoje com parlamentares democratas para d…
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#Internacionales Un total de 1,09 millones de trabajadores españoles han dejado de teletrabajar de manera habitual,…
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Increasing vaccine supply is critical.
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La vacuna contra el coronavirus de Oxford/AstraZeneca es tan eficaz para combatir la variante británica como el vir…
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@oscar_ojea @AuSol_AR @Pontifex_es @DiocesisSI @Infobannoticias @CristianRompani @lauraolivaar @EpiscopadoArg…
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RT @franceinfo: Couvre-feu : "Pas de tolérance, il faut que chacun s’organise" pour les départs en vacances, indique le ministère de l'Inté…
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RT @BritainFree: "People who have not accepted vaccination offers could get knocks on the door from council staff in an attempt to convince…
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RT @NHSMillion: Ministers are planning to use Covid as an excuse to take more control over the NHS in England. Please RT if you think ever…
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RT @Regione_Abruzzo: Didattica a distanza fino al 21 febbraio per gli studenti delle scuole medie superiori #Abruzzo. Zona rossa per i Comu…
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RT @Mippcivzla: 🗣️ ¡𝐄𝐒 𝐂𝐎𝐍𝐓𝐈𝐆𝐎 ! ✍️🇻🇪 Evitar la propagación de las enfermedades respiratorias agudas es evitar la entrada del Coronavirus.…
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RT @elfjcgc: La mismísima Merck, productora de la #ivermectina piden que no se use como preventiva ante el #Covid19
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VÍDEO| En Perales del Puerto, Cáceres, destinan el dinero de las fiestas en comprar purificadores para hacer frente…
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1/2 « La ministre fédérale des Services publics et de l’Approvisionnement, Anita Anand, a souligné devant le Comité…
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RT @NPR: You might soon be able to get vaccinated where your favorite football team plays. Every NFL team will offer their stadium as a po…
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¡Tremenda Noticia Venezuela! Tenemos las primeras 100 mil dosis de la vacuna Sputnik V en nuestro país. Esto es sin…
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Es, sin duda alguna, una noticia histórica y trascendental que nos llena de inmensa alegría y esperanza a todos los…
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Pedro Cavadas entra en la lista Forbes de los mejores médicos el año de sus predicciones sobre el coronavirus
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Post-coronavirus: Ken Ofori-Atta flies to US
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RT @merkur_de: Die deutschen Grenzschließungen sorgen in #Österreich für offene Wut. Das Land bestellt Berlins Botschafter ein - ein Minist…
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« Une organisation de crise » déclenchée dans les hôpitaux via @LObs
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@mailandguardian Another homework for you perhaps opportunity to write a little less biased and more objective to h…
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RT @aajtak: मुख्यमंत्री विजय रुपानी का कोरोना रिपोर्ट पोजिटीव। अहमदाबाद की यूएन मेहता अस्पताल में हैं भर्ती। देखिए संवाददाता @gopimaniar की…
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RT @brasil247: Uso de Ivermectina contra covid está comprometendo fígado de pacientes, dizem médicos
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RT @UnSubtleDesi: The New York Times is at it again! How their Editorial Director tried to cast aspersions on India’s Coronavirus vaccine d…
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RT @tv9gujarati: #Gujarat CM tested positive for #Coronavirus, other ministers to undergo #Covid19 test.
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Arka bahçemden her an bir geyik çıkabilir 🙄😂 Gökçeada donuyor ⛄⛄⛄💃💃 #snow #kar #canakkale #goekceada #COVID19…
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RT @CisneNegroJMAL: ALEMANIA CONTRATÓ A CIENTÍFICOS PARA DESARROLLAR MODELOS DE CORONAVIRUS FALSOS PARA JUSTIFICAR UN CONFINAMIENTO ESTRICT…
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RT @jmmulet: ¿Seríais capaces de detectar un graffiti de Banksy en medio de las meninas de Velázquez? Pues si el coronavirus se hubiera hec…
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Aurélien Arnaud crée du lien sur sa plateforme "Entraide à Montpellier face au coronavirus"
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RT @olimpia_epiro: El 40%! El Banco de España avisa de que el 40% de las empresas no puede cubrir sus gastos financieros - Libre Mercado ht…
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El Banco de España avisa de que el 40% de las empresas no puede cubrir sus gastos financieros…
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RT @merkur_de: Die deutschen Grenzschließungen sorgen in #Österreich für offene Wut. Das Land bestellt Berlins Botschafter ein - ein Minist…
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RT @4Frevolucion2: VENEZUELA VENCE AL CORONAVIRUS▶️#PrevenirEsVencer @AlexRodrilobo @Yulitzavillalo6 @WendyVilla2020 @Aijuna6 @Paola2T @20M…
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(WHO, in their right mind, would want to bring a baby into this MESS of a world?!!!) Baby bust: Why the coronavirus…
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WHO & partners are racing to develop and deploy safe & effective vaccines against #COVID19. Learn more about how vaccines work through a series of short video explainers.
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Dr Soumya Swamunathan explains why #COVID19 vaccines are able to be developed so fast
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Dr Kate O'Brien explains why we can trust the safety of #COVID19 vaccines trials
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During #COVID19 when out and about, make hand sanitizer part of your mask wearing routine
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#ACTogether
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#COVID19
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How is a vaccine approved for production❓ 1⃣ Pre-approval stage following clinical trials 2⃣ Regulatory assessment & approval 3⃣ WHO prequalification & approval 4⃣ Ready for production
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Developing a #vaccine is a long road full of checkpoints. Each phase is designed to make sure it is both effective and safe.
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How do mRNA #COVID19 vaccines work?
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We are all being exposed to a huge amount of #COVID19 information Information source on a daily basis, and not all of it is reliable. Before you share, CHECK trusted sources like WHO/local health authorities
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During the COVID-19 pandemic, you may be asked to quarantine. Watch this video for some advice on how to take care of yourself during that time.
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#COVID19 vaccines
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Today is #ZeroDiscrimination Day⠀ ⠀ 𝗔𝗡𝗬𝗢𝗡𝗘 can contract #COVID19 regardless of race, gender, age or other personal qualities.⠀ ⠀ 𝚆𝚎 𝚗𝚎𝚎𝚍 𝚜𝚘𝚕𝚒𝚍𝚊𝚛𝚒𝚝𝚢, 𝙽𝙾𝚃 𝚜𝚝𝚒𝚐𝚖𝚊 🙅‍♂️🙅‍♀️ in fighting the spread of COVID-19
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The world is waking up to #VaccinEquity!⠀ ⠀ We call on all countries to work in solidarity to ensure vaccine equity and start vaccination of health workers and older people in ALL countries within the first 100 days of 2021. It’s in the best interest of every nation! ⠀ Individuals and organizations everywhere 🌎🌍🌏 are encouraged to join in this crucial effort!⠀ ⠀ Sign the #COVID19 Vaccine Equity declaration 👉 who.int/vaccinequity
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WHO & partners are racing to develop and deploy safe & effective vaccines against #COVID19. Learn more about how vaccines work through a series of short video explainers.
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WHO & partners are racing to develop and deploy safe & effective vaccines against #COVID19. Learn more about how vaccines work through a series of short video explainers.
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WHO & partners are racing to develop and deploy safe & effective vaccines against #COVID19. Learn more about how vaccines work through a series of short video explainers
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WHO & partners are racing to develop and deploy safe & effective vaccines against #COVID19. Learn more about how vaccines work through a series of short video explainers.
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Make a difference and declare your support for #VaccinEquity.⠀ ⠀ ✍️ Sign the WHO declaration calling for #COVID19 vaccines to reach health workers in every country in the first 💯 days of 2021: who.int/VaccinEquity
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Will #COVID19 vaccines work against new virus variants?
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coronavirus Pinterest Ideas
  • coronavirus in cats
  • coronavirus health
  • coronavirus canino
  • coronavirus in humans
  • coronavirus news
  • coronavirus felino
  • feline coronavirus
Feb 13, 2021 17:20
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Jan 31, 2021 14:01
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O principal efeito visto é na frequência cardíaca, que passa a ser mais baixa e, mesmo durante a realização de atividades, não chega a aumentar como antes. Além disso, os vasos se tornam mais rígidos e as paredes das artérias mais espessas, o que favorece o aparecimento de uma condição conhecida como hipertensão sistólica isolada. Vale ressaltar: efeitos como esses podem ser reduzidos com a prática de exercícios físicos, então, que tal fazer uma caminhada hoje e melhorar a saúde do seu coração?⠀ ⠀ #infartonaorespeitaquarentena #sinaldeinfarto #infarto #grupoderisco #coronavirus #pandemia #covid19 #dorno peito #responsabilidade #coracaoalerta #coracaoalertaresponde #coracao #cardio #doutor #medicina #remedio #medicacao #farmacia #saude #health #SBHCI www.coracaoalerta.com.br
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#responsabilidade #covid19 #pandemia #coracaoalertaresponde #farmacia
Jan 31, 2021 14:01
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#nature #landscapephotography #landscape #naturephotography #nature_of_our_world #naturelovers #photooftheday #photography #photographer #mountainlover #mountains #liveyourlife #carpediem #vintage #liveyourlife #lifeforlife #lifestyle #coronavirus #covid19 #cow #nature_perfection #travelphotography #travel #naturegram #landscapelovers #instagood #instagram #instamoment #naturegallery #naturegarden #naturevintage
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#liveyourlife #naturegallery #landscapephotography #travel #naturevintage
Jan 31, 2021 14:01
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Hanseníase é uma doença infecciosa e contagiosa causada pelo bacilo Mycobacterium leprae. Afeta a pele e os nervos periféricos, ocasionando lesões neurais, conferindo à doença um alto poder incapacitante.⠀ ⠀ A transmissão ocorre através das vias aéreas (secreções nasais, gotículas da fala, tosse, espirro) de pacientes sem tratamento. O paciente que está sendo tratado deixa de transmitir a doença, cujo período de incubação pode levar de três a cinco anos. A maioria das pessoas que entra em contato com estes bacilos não desenvolve a enfermidade.⠀ ⠀ A cada ano, cerca de 210 mil mulheres, homens e crianças são diagnosticados com hanseníase, segundo dados da Organização Mundial da Saúde. Até 50% das pessoas afetadas pela hanseníase enfrentarão, além da própria doença, problemas de saúde mental, como depressão ou ansiedade, com risco aumentado de suicídio.⠀ ⠀ #hospital #covid #doctor #medical #nurse #medicine #health #healthcare #doctors #medicina #coronavirus #surgery #medico #nurselife #salud #nursing #o #surgeon #nurses #medstudent #a #clinica #love #enfermagem #saude #medicalstudent #corona #medschool #m
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#medstudent #salud #medicine #health #nurse
Jan 31, 2021 14:01
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⠀ #carmodacachoeira #saude #beleza #vemserinova #mascara #coronavirus #suplemento #vitamina
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#beleza #coronavirus #vitamina #vemserinova #carmodacachoeira
Jan 31, 2021 14:02
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31.01.2021 - 10.00 am දෛනික තත්ත්ව වාර්තාව இலங்கையின் நாளாந்த நிலைமை அறிக்கை Daily Situation Report Real-time updates from www.hpb.health.gov.lk #COVID_19 #CoronaVirus #COVID19 #COVID19SL #COVID2019 Facebook - http://fb.com/hpbSriLanka Follow us on Twitter - @HPBSriLanka
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#coronavirus #covid19sl #covid2019 #covid19 #covid_19
Jan 31, 2021 14:02
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❕GIVEAWAY❕ Trei castigatori vor avea sansa sa isi aleaga una dintre mastile noastre! Vom alege prin extragere( random.org) trei persoane care vor primi fiecare cate o masca la alegere, care vine cu un filtru de protectie tip PM 2.5 inclus❤️ Ce trebuie sa faci❔ 1. Follow @erika.zlota 2.Lasa comentarii in care sa iti etichetezi 3 prieteni (puteti lasa mai multe comentarii insa prietenii sa fie diferiti) 3.Da un share la povestea ta acestui GIVEAWAY Va multumim pentru tot si va asteptam duminica ( 07.02.2021) la ora 00:00 pe profil pentru a afla castigatorul! Succes❕ #byerikazlota #erikazlotamasks #giveaway #giveawaytime #giveawayromania #masks #couture #erikazlotamasks #giveawaycontest #bucuresti #bucharest #masti #coronavirus #protection #love #christmas #international #giveaway #safe #stylish #fashion #design #passion #smallbusiness #gifts #present
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#christmas #giveawayromania #coronavirus #couture #bucharest
Jan 31, 2021 14:02
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Boletim da Covid deste domingo (31/01/2021). Tivemos um óbito ontem, de um homem de 63, que estava internado no Hospital Regional do Oeste. Subiu para 140 o número de chapecoenses vítimas fatais da Covid-19. Os boletins e a ocupação hospitalar podem ser conferidos no site www.chapeco.sc.gov.br/coronavirus. #covid19 #coronavirus #saude #chapeco #prefeituradechapeco
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#prefeituradechapeco #saude #covid19 #coronavirus #chapeco
Jan 31, 2021 14:02
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Let's exercise even though you're in PKP mood. 😜😜 . Let's #staysafe #stayathome #stayhealthy #socialdistancing #flattenthecurve to fight #covid19 #coronavirus
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#coronavirus #stayhealthy #covid19 #staysafe #socialdistancing
Jan 31, 2021 14:03
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Diziyi 3.kez bitirdim şu an hayatım boşlukta... ~Aleyna . 🎶See You Again 🎬How i met your mother 👤@nph @cobiesmulders @joshradnor @alysonhannigan @jasonsegel . . . #howimetyourmother #himym #neilpatrickharris #joshradnor #jasonsegel #alysonhannigan #cobiesmulders #barneystinson #tedmosby #marshalleriksen #lilyaldrin #robinscherbatsky #series #sitcom #netflix #netflixturkiye #usa #newyork #amerika #friends #annenizlenasıltanıştım #kids #2030 #coronavirus #turkey #2020 #tiktok #keşfet #followers #followforfollowback
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#turkey #jasonsegel #himym #marshalleriksen #2020